Endogenous Opioid Peptides in Mammals and their Use as Therapeutic Targets for the Management of Pain
Opioidergic neurotransmission plays a critical role in a variety of biological processes, including analgesia, constipation, respiration, euphoria, sedation, and meiosis. The discovery of receptors for exogenous opiates such as morphine has led to the identification of various endogenous opiates which function as physiological ligands for these receptors.
This patent pending invention describes the identification and characterization of a novel endogenous opioid peptide transporter system and methods of modulating the activity of an opioid by administering an agent that modulates the transmembrane transport of the opioid by the endogenous opioid peptide transport system. The invention further describes methods of treating pain, by administering an effective amount of an agent that inhibits the transmembrane transport of the endogenous opioid by the endogenous opioid peptide transport system method. Methods of reducing the amount of narcotic needed for effective pain management as well as novel compositions modulating the activity of the opioid transport system are also described.
For more information please contact:
Girish Nallur, Ph.D.
Chief Scientific Officer
Competitive Technologies, Inc.
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Tel: 203.368.6044
